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Symantec has just produced a report on spam messages, what they promote and how they attempt to bypass f

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ilters designed to stop spam. The report doesn't really contain any major surprises to me, although it

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

oes confirm what I have been seeing in my own studies.

The overall amount of spam made up 70% of all em

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

il messages, which is lower than several other sources estimate, but it must be remembered that Symantec

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

takes samples from their own sources and spam may have already been filtered (at the network level) prio

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

to entering this sample data.

The big talking point of the report is that Pornographic spam now makes

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

p only 3% of all spam monitored by Symantec. This is the lowest percentage makeup ever recorded. Clear

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ly - pornography isn't selling for spammers the same as other products. Perhaps everyone who needs enla

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ging has got it?

The increase in the amount of spam that uses images continues. As bayesian filters ca

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ch more and more text based spam, the spammers have changed their method of attack to sending pictures o

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

words. This allows them to use randomised text to beat the Bayesian filters, but once opened the text

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s overlapped with an image sending the spammers true message. This is not a new tactic, but it has evol

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ed slightly with the increasingly predominant practice of slanting or distorting the writing on these pi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tures. This is aimed at defeating OCR(Text recognition) software.

The final trend of note in the Syman

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tec report is that non-english speakers are being targeted more than in the past, particularly by casino

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

based spam. French, German and Italian language casino spam has sen a dramatic rise, and picture based

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

pam targets all languages.

On a personal note I have seen an increase in this localisation of spam. I

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ave received no inappropriate language based spam, but I have noted that the distribution of spam to me

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

com vs my .co.nz email addresses has shifted. I suspect that spammers are hitting localised email addre

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ses with localised content, which is undoubtedly where the increase in language specific spam originates

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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