Useful Advices - Business

Whether you presently own a retail or web based business and are looking for an additional profit center or you are thinking of starting a business, jewelry is a “

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

no-brainer” choice for a proven product category. The buying public, (particularly women) never tires of jewelry as the choices in color, materials, finishes and s

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tyles are endless and innovations are continual. Every generation reinvents jewelry for itself in much the same way that it reinvents music and fashion. Styles cha

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nge but the basic facts remain the same. If you are a seasoned professional, please consider the following a refresher course. To the new comer, use this informati

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

n as a foundation for your ongoing jewelry education.

The Facts About Gemstone Jewelry

Natural gemstones are found in nature. Laboratory-created stones, as the n

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ame implies, are made in a laboratory. These stones, which also are referred to as laboratory-grown, {name of manufacturer} - created, or synthetic, have essential

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ly the same chemical, physical and visual properties as natural gemstones. Laboratory-created stones do not have the rarity of naturally colored stones and they ar

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

less expensive than naturally mined stones. By contrast, imitation stones look like natural stones in appearance only, and may be glass, plastic, or less costly s

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tones. Laboratory-created and imitation stones should be clearly identified as such.

Gemstones may be measured by weight, size, or both. The basic unit for weighi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ng gemstones is the carat, which is equal to one-fifth 91/5th) of a gram. Carats are divided into 100 units, called points. For example, a half-carat gemstone woul

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

weigh .50 carats or 50 points. When gemstones are measured by dimensions, the size is expressed in millimeters (for example, 7x5 millimeters).

Gemstone treatmen

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ts or enhancements refer to the way some gems are treated to improve their appearance or durability, or even change their color. Many gemstones are treated in some

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

way. The effects of some treatments may lessen or change over time and some treated stones may require special care. Some enhancements also affect the value of a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

stone, when measured against a comparable untreated stone.

Jewelers should tell you whether the gemstone you’re considering has been treated when: the treatment i

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

not permanent; the treated stone requires special care; or the treatment significantly affects the value of the gemstone.

Some common treatments that you may be

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

told about and their effects include:

• Heating can lighten, darken or change the color of some gems, or improve a gemstone’s clarity.

• Irradiation can add more

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

color to colored diamonds, certain other gemstones and pearls.

• Impregnating some gems with colorless oils, wax or resins makes a variety of imperfections less

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

isible and can improve the gemstones’ clarity and appearance.

• Fracture filling hides cracks or fractures in gems by injecting colorless plastic or glass into th

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e cracks and improves the gemstones’ appearance and durability.

• Diffusion treatment adds color to the surface of colorless gems; the center of the stone remains

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

colorless.

• Dyeing adds color and improves color uniformity in some gemstones and pearls.

• Bleaching lightens and whitens some gems, including jade and pearls

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Useful Advices - Buying Jewelry For Your Business Part 3: Buying Gemstone Jewelry

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