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    There is only one way under heaven to get anybody to do anything. Have you ever thought about that? It is by making the other person, want, to do what you want them to d
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    o.

    Of course, you can make anyone hand over their watch or wallet, by pointing a gun in their face, or an employer can force his employees to cooperate, by threatening
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    to fire them. Even a child will do as he or she is told if they are threatened. But with these crude methods come undesirable repercussions.

    Only by giving you what you
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    want, will you do as I ask, Is that not True? The question is, What do you want? Sigmund Freud said that everything you or I do, springs from two motives. Sexual desir
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    e, and the desire to be great! Dr John Dewey another profound philosopher, phrased it in these words "The Deepest urge in human nature is the desire to be important", Ye
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    s, importance is something that man has always strived for. Here is a thought for you to ponder, What do you want?

    I hesitate to say the majority of people would not wa
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    nt too many things, but the few things you do wish, you crave, is this not true with most of us. Think about it seriously.Some of these things could include:

    Health and
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    fitness,
    Food,
    Sleep,
    Money and the things money Buys,
    Life after Death,
    Sexual Gratification,
    The Well being of our children,
    The fe
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    eling of importance.

    Almost all of these wants are usually gratified except one. Its almost as deep as the desire for food or sleep "The Desire to be Important" Linco
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ln started a letter saying "Everybody likes a compliment!" William James said, "The Deepest Principle in human nature is the craving to be appreciated", He did not speak
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    , of the "wish" or the "desire" to be appreciated.

    A great man once said "I consider my ability to arouse enthusiasm among people". The Greatest asset I possess, and th
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    e way to develop the best in a person, is by appreciation and encouragement. "There is nothing else that so kills the ambitions of a person as criticisms, from superior
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    s. I try never to criticize anyone, rather I would prefer to teach someone in order to try to give that person the incentive to work.

    Sometimes you will find readers
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    saying they have heard it all before, or' You tried it all and it does not work, at lest, not for intelligent people, they flatter themselves. And you would be right, f
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    lattery seldom works, with discerning people. Flattery is usually shallow, insincere, and can show selfishness on their behalf.

    The Difference between Appreciation and
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    Flattery?

    Easy! One is sincere, the other is insincere, one comes from the heart, the other from the head, if all we had to do was flatter, everyone would catch on, and
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    we would all be experts in Human relations. Flattery is easy to hand out, it can puff up the receiver and the one handing it out as a compliment but appreciation on th
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    e other hand takes time. And does not come as easy as we would like.

    In my experience appreciation comes with experience, and time, and usually comes when its too late.
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    We may at times believe, in ourselves, that we appreciate certain things in life, but have a rude awakening when the thing, we loved or person, we loved is taken from u
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    s. Only when one has experienced, the school of hard knocks, can one truly understand the word Appreciate.

    Principle #2
    Always Give Honest and Sincere Appreciation


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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