Useful Advices - Business

While channel surfing the other night, I happened upon a replay of the 1980's hit film The Karate Kid. Although it's not the greatest movie ever to come out of Hollywood, I can't stop thinking about the relevance of this film in both my personal life and

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

my work surrounding Generation Why.

For me, the profound teaching point in the movie happens when Mr. Miyagi gets total buy-in from his 16-year-old student, Daniel. As you may remember, Daniel was continually tormented by a band of neighborhood bullies. One n

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ght, as he is getting badly beaten by five other kids, Miyagi jumps in from out of the shadows and single-handedly fights off all the attackers to rescue Daniel. Completely stunned that the quiet, elderly maintenance man at his apartment complex is also an expe

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

t in martial arts, Daniel approaches Miyagi, seeking to learn how to defend himself. The reluctant sage finally consents to instruct the young lad, with the stipulation that the lessons will be taught on Miyagi's uncompromising terms.

As the eager boy shows up

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

for his first lesson, he assumes Miyagi is immediately going to begin teaching him how to punch and kick. Instead, Miyagi plants a sponge firmly in the palm of Daniel's hand and orders him to wash and wax a half-dozen large cars. "Wax on, wax off," Miyag

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

commands. Naturally, the flabbergasted teen starts to question the assignment, but Miyagi abruptly silences him with these words: "No questions! That's the deal. I say, you do. Wax on, right hand, wax off, left hand. Make large circles. Breathe in through n

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ose, out through mouth. Very important."

It takes all day and half the night, but Daniel completes the chore and is totally exhausted, only to be instructed by Miyagi to return at 6 the next morning. This pattern continues for several days as Daniel shows

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

p expecting to learn karate, only to be disappointed again and again when Miyagi puts him to work doing monotonous household chores. Daniel has to follow very specific instructions for hours on end without any explanation as to why.

At the end of the week, Dan

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

el finally hits his breaking point and is about to storm off when Miyagi decides the time has come to reveal the method behind his madness. He orders Daniel to use his "wax on, wax off" hand movements as he reaches in to punch him. The boy quickly discov

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rs that he'd actually been practicing sophisticated karate techniques the entire week--that by repeating the same motions while painting fences, sanding decks, and washing and waxing cars, he'd actually mastered the very moves needed to defend himself from his

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ttackers.

Daniel is euphoric to discover his new set of skills and becomes an even more disciplined student for Miyagi. And, following the familiar Hollywood template, he eventually goes on to defeat his enemies, win the girl, and live happily ever after.

But

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

this movie is so twentieth century …

In today's world, no kid blindly conforms to the "I say, you do" method of instruction without a full explanation of what they are doing and what's in it for them. Today's teens want all the details up front. It's e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ough to drive you whacko!

There are times when parents, teachers, and managers can't afford the luxury of explaining the rationale behind every order they give to their kids, students, and employees. It's at these tense moments when we all wish we could instan

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ly channel the magic of Miyagi to get our young cohorts to do as we say without questioning why.

Alas, my kindred souls, keep in mind that the magic of Miyagi doesn't happen overnight, even in the movies. In this push button, hurry-up, nano-second world, there

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

are no shortcuts to developing loyal young employees who consistently give you their very best.

Let's take a moment to examine the three principles Miyagi drew upon that enabled him to penetrate the heart and mind of his young, stubborn prot?g?:

1. Trust.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

/b>Miyagi was always very up front and honest with Daniel, so the young man knew that Miyagi would neither abandon nor manipulate him if he took him on as a student. Daniel recognized that Miyagi had his best interests at heart; as a result, Daniel followed Miy

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

agi's orders to the letter, even though the old man's methods were unconventional.

2. Respect. Daniel had seen Miyagi in action, and he knew the old man possessed the skills he desperately wanted to learn. Firmly convinced that Miyagi could help him, Da

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

iel was willing to accept the "I say, you do" terms laid out before the training began.

3. Timing. When the student was ready, the teacher appeared. Miyagi didn't begin with a mind dump of self-defense techniques; instead, he held off on starting

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the lessons until Daniel's desire to learn was fully piqued. If Miyagi hadn't brought Daniel along slowly, it's likely Daniel would have quickly forgotten the techniques rather than internalizing them at the deepest level.

Okay, so it's just a Hollywood movie

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ith a simple plot. But this script can come alive in your workplace if you breathe deep (very important) and remember that you must begin to shape and care for your young bonsai trees today if you want them to grow to be worthy of pride and praise in the future

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Useful Advices - Wax On, Wax Off - Channeling the Magic of Miyagi

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