Useful Advices - Business

Packaging tapes come in many different forms and trying to ascertain the correct tape for the job can be a frustrating & complex process. From experience, the majority of people tend to find a suitable solution only after a sometimes painful and potentially expensive learning curve when the material has failed to achieve its

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

intended role. This trial & error method is in the most part unnecessary providing people are made aware of a few basic rules governing the properties & performance of the tape.

Tape make-up

Packaging tapes are in the main self adhesive and consist of a backing material known as the “carrier” and a layer of

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

adhesive attached to one side. Differing carriers and adhesives are combined for a variety of applications. The most common types of carrier are PVC (poly vinyl chloride), polypropylene and kraft paper. These days polypropylene and kraft paper based tapes are becoming more popular due to their lower environmental impact when

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

compared with PVC based tapes. The adhesives used in the tape have also evolved in recent years. Solvent based adhesive used to be the adhesive of choice, however hot melt and water based acrylic have now overtaken solvents as the preferred tape adhesive. It is important when choosing a tape to be aware of the different type

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s of adhesive as this will govern how effective the final result is.

Tape application

As already mentioned, most packaging tapes are self adhesive and this adhesive tends to be pressure sensitive. This means that in order to achieve the tape manufacturers’ intended performance the tape must be applied with so

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e form of applicator or dispenser. Although seemingly obvious it is amazing that most people do not seem to be aware that this is one of the most common reasons that tapes fail to perform. By applying pressure to the tape, the adhesive is activated, bonding properly with the surface to be adhered too and is less likely to fa

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

il at a later point. Firm, consistent pressure should be applied for best results. When applying the edges of the tape to a surface, care should be taken to ensure that pressure is applied firmly to these areas. The ends of the tape, once cut tend to be uneven and are therefore the most vunerable. If these areas are not atta

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hed correctly, the tape is liable to lift away as the adhesive does not have maximum purchase on the material

For most adhesive tapes the adhesive is also time sensitive and needs to be given a chance to bond with the opposing surface. This means that to achieve optimum results it must be left for at least 20 minutes withou

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

t interference. This is an average guide time as some tapes can take longer than this to achieve top results. The main thing to remember on this point is that once applied, the longer it is left without interference or contact then the better the final results.

Another major factor involved in a tapes performance is the mat

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rial that the tape is to be applied to. For best results again, the surface(s) must be clean, dry, free of oil, grease, dirt, dust, fibres, or any other loose material. If any of these substances are present on the surface of the material they will adhere to the tapes adhesive thereby reducing the tapes overall effectiveness

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

. The surface area that the tape is adhered to will be diminished and consequently the tapes abilities will be affected. Ideally the material to be adhered to should be flat and even. This is not always possible of course, however if a surface is uneven or inconsistent, the adhesive will have to work harder to achieve good r

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

esults. In this case it may be necessary to apply extra tape in order to provide added security.

Tape types & features

The most common types of packaging tapes are as follows;

Hot melt polypropylene. Consists of a polypropylene carrier and hotmelt adhesive. Low cost solution for general applications,

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

articularly suitable for high speed volume use. Tends to have a quick release coating on the adhesive for ease of application. Will not tear but susceptible to splitting and can fracture on impact. Requires fair amount of pressure when applied to achieve results. Adhesive performs well in extreme temperatures e.g. cold stora

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ge. Can be overprinted cost effectively.

Acrylic polypropylene. Consists of a polypropylene carrier and water based acrylic adhesive. Low cost solution for general applications such as carton sealing. Will not tear but susceptible to splitting and can fracture on impact. Requires fair amount of pressure when applied

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o achieve results. Can be overprinted cost effectively. Good print reproduction. Available in a user friendly low noise version.

Solvent polypropylene. Consists of a polypropylene carrier and solvent adhesive. Higher priced solution for general applications such as carton sealing. Will not tear but susceptible to spl

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

itting and can fracture on impact. Requires minimal pressure when applied to achieve results. Good adhesion but becoming less popular due to environmental impact. Can be overprinted.

PVC (Polyvinylchloride). Consists of a PVC carrier and a solvent adhesive. Expensive quality solution for most applications such as car

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

on sealing. Can be torn by hand but susceptible to splitting and can fracture on impact. Requires minimal pressure when applied to achieve results. Good adhesion but becoming less popular due to environmental impact. Can be overprinted.

Self adhesive paper tape. Consists of a kraft paper carrier and a water based acr

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ylic adhesive. Expensive good quality solution for general applications such as carton sealing. Can be torn by hand. Excellent adhesion, requires minimal pressure when applied to achieve results. Fast becoming the tape of choice for environmentally conscious users due to its biodegradable and recycling properties. Can be ove

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

printed.

Tapes & recommended applications

Below is a list of typical applications and the recommended tape for that application:

Cardboard normal conditions – Self adhesive paper and polypropylene water based acrylic
Cardboard extreme temperature and high volume – Hot melt polypropylene
Pape

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r normal conditions - Self adhesive paper and polypropylene water based acrylic
Paper extreme temperatures - Hot melt polypropylene
Polythene all conditions – PVC, Solvent polypropylene, polypropylene water based acrylic
Plastics all conditions – PVC, Solvent polypropylene, polypropylene water based acrylic

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Useful Advices - Packaging Tapes Made Easy: How To Choose & Use The Right Tape For Your Application

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