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What’s no bigger than a flip phone comes in fashion colors and can weigh up to 50 grams with .01g accuracy? Don’t look now, but the traditional jewe

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ler’s traveling scale is all fashioned out and style conscious. Pocket scales, used by jewelers, hunters and field investigators for dozens of uses,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

have taken the same route that turned cell phones into fashion accessories. You can now buy pocket scales that weigh less than a pound and are the s

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ize of a small flip phone – yet still promise to weigh substances with accuracy up to .01g – one hundredth of a gram. They come tricked out in camou

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lage, flames, translucent blue ice and hot baby doll pink. These are not your Uncle Jake’s pocket scales, son.

There are more modern uses for pocke

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

scales as well. Chemists and chefs find them handy for measuring minute, precise amounts of chemicals and ingredients, and according to at least on

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e manufacturer, many law officers now carry a pocket scale with them for a quick preliminary reading on the amount of illegal substances found in se

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rches and traffic stops.

Some of the more unusual and notable features of particular models of pocket scales on the market now include:

A Pocket B

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

eam Balance Scale

One of the most clever pocket scales on the market is American Weighs Twin Beam Pocket Balance. Priced as low as $9.95, it measur

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s up to 7 grams (35 ct) with .05 g (.25 carat) accuracy. No batteries needed – it’s the only pocket size balance scale on the market.

Blade Pocket

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

cales

Blade pocket scales feature a retractable digital display that folds into the unit when not in use. They work like a switchblade – thus their

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

name – and the unique, innovative design has made them one of the manufacturers’ most popular products.

CD Pocket Scales

They look just like a CD

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

– until you open the cover. Inside is a precision balanced digital scale, accurate to within .01 g. The CD pocket scales are available in a number o

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

f covers – or you can insert your own to fit your CD collection.

Some features to look for when you’re comparing pocket scales include the followin

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

:

Capacity/Accuracy

The capacity is the largest weight which the scale is capable of handling. Accuracy is the smallest increment of weight that t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e scale will read. A scale with a capacity/accuracy of 7g/.25g will weigh up to 7 grams with accuracy to within one quarter of a gram.

Protection

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Because you’ll be carrying the scale with you, it’s important to buy one that’s designed with protection of the delicate mechanics in mind. Look for

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rigid covers that prevent anything from resting on the weighing surface.

Expansion Trays

One of the nicer features of some pocket scales is a cove

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r that doubles as an expansion scale, making it easy to weigh things that are too large for the weighing surface. Expansion trays also mean that dus

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

and residue doesn’t remain on the weighing surface itself – you just wipe out the expansion tray instead of scraping the surface.

© Ben Anton, 200

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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